NBIO Presents: Jhimmy Talbot (Fred Hutchinson Cancer Research Center)

Neural regulation of intestinal immune and absorptive functions

The intestinal mucosa serves both as a conduit for the uptake of food-derived nutrients and microbiome-derived metabolites, and as a barrier that prevents tissue invasion by microorganisms. How the intestine coordinates physiological responses to food consumption to optimize nutrient uptake while maintaining barrier functions remains unclear. My lab’s goal is to develop a comprehensive understanding of how the gut balances these competing metabolic and immune needs. Using genetically modified mouse models we have identified neuronal circuits activated by diet and microbes that coordinate intestinal immunity and host nutrition. Our studies may reveal how changes in diet or the microbiota lead to metabolic dysfunctions and provide insights into how pathogens hijack neurons to facilitate infection.

Health Science G 328 and on Zoom