Hybrid Event
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NBIO Presents: Christopher Lapointe, PhD (Fred Hutchinson Cancer Center)
February 12 @ 9:30 am – 10:30 am
Hybrid Event
“Dynamic branchpoints regulate selection of translation start codons”
To establish the reading frame for protein synthesis, the human translation initiation machinery must recognize the translation start codon (AUG) with single-nucleotide precision. Yet, foundational studies in the 1980’s demonstrated that non-AUG start codons (e.g., CUG) can also drive protein synthesis. More recent studies indicate widespread and regulated use of non-AUG codons, with critical roles in the cell cycle, stress responses, and disease. I will share how we have been applying single-molecule, biochemical, and structural strategies to understand how the initiation machinery balances the need for both precision and flexibility.
Health Sciences G-328 and Zoom.
