NBIO Presents: Jayeeta Basu, PhD (New York University)

Cortico-Hippocampal Circuit Interactions in Shaping Learning and Memory Representations

Flexibility and stability of neuronal ensembles are crucial features of brain function. Little is known about how these properties of local circuits are influenced by long-range inputs. We show, in mice, that lateral entorhinal cortex glutamatergic  and GABAergic  projections to CA3 recruit specific microcircuits that conjunctively provide stability to neuronal ensembles, thereby supporting learning. Furthermore, circuit mapping and manipulations of hippocampal back-projections to entorhinal cortex in mice show anatomically and functionally distinct hippocampal feedback pathways to deep and superficial layers of the medial entorhinal cortex that differentially modulate excitation-inhibition dynamics, plasticity, and novelty driven behavioral output.

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