Development and regeneration of synaptic circuits in the vertebrate retina
Our lab is interested in neural circuit assembly in development, circuit disassembly in degeneration and circuit reassembly upon cellular regeneration. Our current studies are based on the vertebrate retina of mice, human and non-human primates. We apply a diversity of approach including in vivo and in vitro confocal and multiphoton imaging, serial block-face scanning electron microscopy, transgenic methods and electrophysiology to investigate neuronal structure, function and connectivity in normal and perturbed retinas.
Selected Publications:
Circuit Reorganization Shapes the Developing Human Foveal Midget Connectome toward Single-Cone Resolution.
Zhang C, Kim YJ, Silverstein AR, Hoshino A, Reh TA, Dacey DM, Wong RO. Neuron. 2020 Oct 6:S0896-6273(20)30714-5. * Cover image
LRRTM4: A Novel Regulator of Presynaptic Inhibition and Ribbon Synapse Arrangements of Retinal Bipolar Cells.
Sinha R, Siddiqui TJ, Padmanabhan N, Wallin J, Zhang C, Karimi B, Rieke F, Craig AM, Wong RO, Hoon M. Neuron. 2020 105(6):1007-1017.
Distinct Developmental Mechanisms Act Independently to Shape Biased Synaptic Divergence from an Inhibitory Neuron.
Gamlin CR, Zhang C, Dyer MA, Wong RO. Curr Biol. 2020 Apr 6;30(7):1258-1268.
Dynamic assembly of ribbon synapses and circuit maintenance in a vertebrate sensory system.
Okawa H, Yu WQ, Matti U, Schwarz K, Odermatt B, Zhong H, Tsukamoto Y, Lagnado L, Rieke F, Schmitz F, Wong RO. Nat Commun. 2019 May 15;10(1):2167.
Synaptic Convergence Patterns onto Retinal Ganglion Cells Are Preserved despite Topographic Variation in Pre- and Postsynaptic Territories.
Yu WQ, El-Danaf RN, Okawa H, Pacholec JM, Matti U, Schwarz K, Odermatt B, Dunn FA, Lagnado L, Schmitz F, Huberman AD, Wong RO. Cell Rep. 2018 25(8):2017-2026.