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X-WR-CALDESC:Events for UW Neurobiology & Biophysics
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DTSTART;TZID=America/Los_Angeles:20260609T160000
DTEND;TZID=America/Los_Angeles:20260609T171500
DTSTAMP:20260628T063301
CREATED:20251126T192949Z
LAST-MODIFIED:20260601T164251Z
UID:10000119-1781020800-1781025300@nbio.uw.edu
SUMMARY:Wayne E. Crill Endowed Lecture: Kristen Brennand\, PhD (Yale University)
DESCRIPTION:Gene x Environment Interactions in Brain Disease\nKristen Brennand\, PhD\, Professor in Psychiatry & Genetics at Yale University School of Medicine \nAbstract: Each person’s distinct genetics and environment predispose them to some phenotypes and confers resilience to others. We seek to understand the genetic regulation of phenotype\, and how it is impacted by developmental\, cellular\, and environmental contexts. Our functional genomics approach integrates human induced pluripotent stem cell models with\nCRISPR-based genome engineering to introduce and reverse genetic variation\, yielding precision models that can be combined with genetic and pharmacological screens. Given the complex genetic risk architectures associated with psychiatric disorders and neurodegenerative diseases\, we ask how diverse risk variants share convergent downstream impacts\, and whether when added together\, combinatorial perturbations yield outcomes that cannot yet be predicted by individual manipulations alone. Likewise\, we ask how stress\, inflammation\, hormones\, and other exposures exacerbate or ameliorate the effect of disease-associated risk factors. We study how genotype-phenotype relationships vary across people and dynamic conditions\, within and between the cell types of the brain. Thus\, rather than just characterize the impact of trait-associated variants\, we seek to uncover modifiers that alter it. Our goal is to decipher the frameworks that buffer genetic risk\, in order to confer biological resilience and promote healthy development. Understanding the basic biology governing the complex interplay between genetic variants and the environment will springboard the development of novel\, personalized approaches to improve health and prevent brain disease
URL:https://nbio.uw.edu/event/wayne-e-crill-endowed-lecture-kristen-brennand-phd-yale-university/
LOCATION:Foege Genome Sciences Auditorium S-060\, 3720 15th Ave NE\, Seattle\, WA\, 98195\, United States
CATEGORIES:Seminar
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ORGANIZER;CN="UW NBIO":MAILTO:nbio@uw.edu
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DTSTART;TZID=America/Los_Angeles:20260611T093000
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CREATED:20250909T184606Z
LAST-MODIFIED:20260604T165549Z
UID:10000108-1781170200-1781173800@nbio.uw.edu
SUMMARY:NBIO Presents: Kara Marshall\, PhD (Baylor College of Medicine)
DESCRIPTION:Feeling the Force: PIEZO ion channels in interoception\nAbstract:  The Marshall lab studies how mechanosensory molecules and cells—those that sense forces like pressure and stretch—regulate physiology. Inside our bodies\, various organs distend and contract as they perform their functions\, and embedded neurons monitor and transmit the resulting mechanical sensations to the brain to guide the appropriate behaviors. For example\, stretch sensors in the stomach initiate digestion and mediate the sensation of fullness\, and bladder stretch alerts us to find a bathroom. Despite their importance\, the mechanosensory systems that govern these processes are not well understood. We previously have found that the mechanosensory PIEZO ion channels are critical for a number of interoceptive functions\, and we continue using these sensors as genetic handles to understand how mechanosensation contributes to physiology in health and disease
URL:https://nbio.uw.edu/event/nbio-presents-kara-marshall-baylor-college-of-medicine/
LOCATION:Health Sciences G-328
CATEGORIES:Seminar
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ORGANIZER;CN="UW NBIO":MAILTO:nbio@uw.edu
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