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SUMMARY:NBIO Presents:  Arif Hamid\, PhD (University of Minnesota Twin Cities)
DESCRIPTION:On the Principles of Dopamine Release in Dorsal Striatum\nIn this talk\, I will present evidence that dopamine (DA) release across the striatum unfolds not as a global broadcast but as structured spatiotemporal waves that tailor reward signals to the computational specialties of distinct frontostriatal circuits. I will argue that these waves resolve a key spatiotemporal credit assignment problem by vector-weighting regional decision signals to facilitate a dynamic reprioritization of policy gating. I will outline our recent analysis of fundamental activational principles\, demonstrating that DA fluctuations follow lawful\, linear oscillatory dynamics captured by a generalized DA wave equation\, and provide empirical evidence for circuit interactions that generate\, propagate\, and constrain these DA activity primitives. Together\, our studies provide an empirically informed revision of an enduring “global broadcast” hypothesis about DA-RPE signals\, clarifying the circuit and dynamical mechanisms underlying DA’s role in reinforcement learning. \n Health Sciences G328 and Zoom
URL:https://nbio.uw.edu/event/nbio-presents-arif-hamid-university-of-minnesota-twin-cities-2/
LOCATION:Health Sciences G-328
CATEGORIES:Seminar
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SUMMARY:NBIO Presents:  Xiaoyin Chen\, PhD (Allen Institute)
DESCRIPTION:Understanding brain variations using scalable barcoded connectomics and spatiomics\nHumans and other animals exhibit a wide range of behaviors that are both species-specific and variable within a species. Both types of behavioral variations are enabled by genetic\, molecular\, and circuit variations in the brain. Mapping and comparing brain-wide variations at cellular resolution across a population\, however\, remains a tremendous challenge. My lab aims to solve this challenge by developing in situ sequencing and barcoded connectomics tools. These tools are scalable to brain-wide interrogation across populations and sufficiently low-cost to be applied by individual labs\, and allow us to understand molecular and circuit variations with unprecedented details. In this talk\, I will discuss three related studies in which we use these approaches to reveal how the visual cortex and thalamus develop and adapt from mouse to marmoset and macaque. Finally\, I will discuss preliminary data that aim to reveal how individual variations impact brain-wide organization at the molecular level. \n Health Sciences G328 and Zoom
URL:https://nbio.uw.edu/event/nbio-presents-xiaoyin-chen-allen-institute-2/
LOCATION:Health Sciences G-328
CATEGORIES:Seminar
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