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X-WR-CALDESC:Events for UW Neurobiology & Biophysics
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DTSTART;TZID=America/Los_Angeles:20260204T133000
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SUMMARY:CNC Presents: Andrea Stocco\, PhD (UW Psychology)
DESCRIPTION:“Computational Phenotyping of Forgetting”\nAbstract: \nForgetting is among the most salient aspects of long-term memory\, yet it is not directly observable\, posing a fundamental challenge for theory. In this talk\, I argue that forgetting is best captured as a latent computational process that can be inferred through computational phenotyping—the use of formal models of cognition to estimate theoretically meaningful parameters from behavior. I will present a series of experiments showing that parameters governing forgetting can be reliably identified at the individual level\, remain stable across time\, and provide diagnostic leverage beyond surface performance measures. \nI will then introduce preliminary EEG and fMRI evidence linking these computational phenotypes to neural dynamics\, providing converging constraints on the underlying mechanisms. Together\, these results inform a long-standing theoretical debate in memory research: whether forgetting reflects the decay of memory representations or a progressive failure of access to otherwise intact representations. More broadly\, this work illustrates how computational phenotyping can serve as a bridge between cognitive theory\,  neural data\, and clinical applications\, enabling stronger tests of mechanistic accounts of memory.
URL:https://nbio.uw.edu/event/cnc-presents-andrea-stocco-phd-uw-psychology/
LOCATION:Health Sciences K-069
CATEGORIES:Seminar
ATTACH;FMTTYPE=image/png:https://nbio.uw.edu/wp-content/uploads/2026/02/Screenshot-2026-02-02-at-1.43.42-PM-e1770068695445.png
ORGANIZER;CN="UW Computational Neuroscience Center (CNC)":MAILTO:compneuro@u.washington.edu
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DTSTART;TZID=America/Los_Angeles:20260205T190000
DTEND;TZID=America/Los_Angeles:20260205T210000
DTSTAMP:20260424T232932
CREATED:20260107T223800Z
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SUMMARY:CNC Presents Future Tense: Ryan Calo\, JD (University of Washington School of Law)
DESCRIPTION:Future Tense is a series featuring scientists\, thinkers\, and writers discussing the intersections of neuroscience\, artificial intelligence and society. On February 5\, join us for a presentation from UW Law professor Ryan Calo on legal and regulatory approaches to emerging technology.\n\n\n\nLaw and Technology: A Methodical Approach\nTechnology exerts a profound influence on contemporary society\, shaping not just the tools we use but the environments in which we live. Law\, uniquely among social forces\, is positioned to guide and constrain the social fact of technology in the service of human flourishing. Yet\, technology has proven disorienting to law: it presents itself as inevitable\, makes a shell game of human responsibility\, and daunts regulation. Drawing lessons from communities that critically assess emerging technologies\, this book challenges the reflexive acceptance of innovation and critiques the widespread belief that technology is inevitable or ungovernable. It calls for a methodical\, coherent approach to the legal analysis of technology—one capable of resisting technology’s disorienting qualities—thus equipping law to meet the demands of an increasingly technology-mediated world while helping to unify the field of law and technology itself. \nBio\nRyan Calo is the Lane Powell and D. Wayne Gittinger Professor at the University of Washington School of Law. He is a founding co-director (with Batya Friedman and Tadayoshi Kohno) of the interdisciplinary UW Tech Policy Lab and a co-founder (with Chris Coward\, Emma Spiro\, Kate Starbird\, and Jevin West) of the UW Center for an Informed Public. Professor Calo holds a joint appointment at the Information School and an adjunct appointment at the Paul G. Allen School of Computer Science and Engineering. \nProfessor Calo’s research on law and emerging technology appears in leading law reviews (California Law Review\, Columbia Law Review\, Duke Law Journal\, UCLA Law Review\, and University of Chicago Law Review) and technical publications (MIT Press\, Nature\, Artificial Intelligence) and is frequently referenced by the national media. His work has been translated into at least four languages. Professor Calo has testified four times before the United States Senate\, most recently providing witness testimony on July 11\, 2024\, before the United States Senate Committee on Commerce\, Science and Transportation at a hearing titled “The Need to Protect Americans’ Privacy and the AI Accelerant.” Professor Calo stressed the importance of a comprehensive federal privacy law that both protects Americans’ personal privacy and sets guidelines for businesses developing and implementing AI technology. \n\nHealth Sciences Building K-069
URL:https://nbio.uw.edu/event/computational-neuroscience-center-presents-future-tense-ryan-calo-jd-university-of-washington-school-of-law/
LOCATION:Magnuson Health Sciences Center\, University of Washington\, NE Pacific Street\, Seattle\, WA\, 98195\, United States
CATEGORIES:Seminar
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ORGANIZER;CN="UW Computational Neuroscience Center (CNC)":MAILTO:compneuro@u.washington.edu
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BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20260212T093000
DTEND;TZID=America/Los_Angeles:20260212T103000
DTSTAMP:20260424T232932
CREATED:20250909T202446Z
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SUMMARY:NBIO Presents: Christopher Lapointe\, PhD (Fred Hutchinson Cancer Center)
DESCRIPTION:“Dynamic branchpoints regulate selection of translation start codons”\nTo establish the reading frame for protein synthesis\, the human translation initiation machinery must recognize the translation start codon (AUG) with single-nucleotide precision. Yet\, foundational studies in the 1980’s demonstrated that non-AUG start codons (e.g.\, CUG) can also drive protein synthesis. More recent studies indicate widespread and regulated use of non-AUG codons\, with critical roles in the cell cycle\, stress responses\, and disease. I will share how we have been applying single-molecule\, biochemical\, and structural strategies to understand how the initiation machinery balances the need for both precision and flexibility. \n Health Sciences G-328 and Zoom.
URL:https://nbio.uw.edu/event/nbio-presents-christopher-lapointe-phd-fred-hutchinson-cancer-center/
LOCATION:Health Sciences G-328
CATEGORIES:Seminar
ATTACH;FMTTYPE=image/jpeg:https://nbio.uw.edu/wp-content/uploads/2025/09/Christopher-Lapointe-Crop-scaled-e1770069687899.jpg
ORGANIZER;CN="UW NBIO":MAILTO:nbio@uw.edu
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DTSTART;TZID=America/Los_Angeles:20260219T093000
DTEND;TZID=America/Los_Angeles:20260219T103000
DTSTAMP:20260424T232932
CREATED:20250905T203007Z
LAST-MODIFIED:20260403T165129Z
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SUMMARY:NBIO Presents:  Dorian McGavern\, PhD (NINDS)
DESCRIPTION:“Immunological Defense of Dynamic Vascular Barriers in the CNS”\nAbstract coming soon. \n Health Sciences G328 and Zoom
URL:https://nbio.uw.edu/event/nbio-presents-dorian-mcgavern-phd-national-institute-of-neurological-disorders-and-stroke/
LOCATION:Health Sciences G-328
CATEGORIES:Seminar
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ORGANIZER;CN="UW NBIO":MAILTO:nbio@uw.edu
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DTSTART;TZID=America/Los_Angeles:20260226T093000
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SUMMARY:NBIO Presents: Christopher Fortenbach\, MD\, PhD\, (University of Washington\, Department of Ophthalmology)
DESCRIPTION:Photochemical Vision Restoration in Outer Retinal Degeneration \nAge-related macular degeneration and retinitis pigmentosa are the most common causes of blindness in high-income countries. These forms of outer retinal degeneration result in progressive loss of photoreceptor cells while the inner retina largely remains structurally intact. While current therapies to address this vision loss are limited\, a promising strategy involves the intravitreal injection of small molecules known as photoswitches. These photochemical ligands restore light-mediated responses by binding to surviving inner retinal neurons and blocking ion channels in a conformation-dependent manner. Upon absorbing light of a particular wavelength\, they undergo a cis-trans isomerization\, resulting in a light-dependent electrical response that can be conveyed to downstream neurons. Unlike surgical implants or viral-mediated gene therapies\, photoswitches are titratable and upgradable as newer therapies become available. My laboratory develops and studies a novel class of photoswitches designed to target upstream retinal neurons and restore retinal signaling. We investigate the mechanisms by which these ligands act on the retina using a combination of electrophysiological techniques\, and we quantify the retina’s encoding capacity in response to visual stimuli. Ultimately\, by improving our understanding of how photoswitch structure influences the restoration of retinal signaling\, we aim to design better therapies that more closely mimic native visual signaling. 
URL:https://nbio.uw.edu/event/nbio-presents-christopher-fortenbach-md-phd-university-of-washington-department-of-ophthalmology/
LOCATION:Health Sciences G-328
CATEGORIES:Seminar
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ORGANIZER;CN="UW NBIO":MAILTO:nbio@uw.edu
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