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X-WR-CALNAME:UW Neurobiology & Biophysics
X-ORIGINAL-URL:https://nbio.uw.edu
X-WR-CALDESC:Events for UW Neurobiology & Biophysics
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DTSTART;TZID=America/Los_Angeles:20260609T160000
DTEND;TZID=America/Los_Angeles:20260609T171500
DTSTAMP:20260625T084404
CREATED:20251126T192949Z
LAST-MODIFIED:20260601T164251Z
UID:10000119-1781020800-1781025300@nbio.uw.edu
SUMMARY:Wayne E. Crill Endowed Lecture: Kristen Brennand\, PhD (Yale University)
DESCRIPTION:Gene x Environment Interactions in Brain Disease\nKristen Brennand\, PhD\, Professor in Psychiatry & Genetics at Yale University School of Medicine \nAbstract: Each person’s distinct genetics and environment predispose them to some phenotypes and confers resilience to others. We seek to understand the genetic regulation of phenotype\, and how it is impacted by developmental\, cellular\, and environmental contexts. Our functional genomics approach integrates human induced pluripotent stem cell models with\nCRISPR-based genome engineering to introduce and reverse genetic variation\, yielding precision models that can be combined with genetic and pharmacological screens. Given the complex genetic risk architectures associated with psychiatric disorders and neurodegenerative diseases\, we ask how diverse risk variants share convergent downstream impacts\, and whether when added together\, combinatorial perturbations yield outcomes that cannot yet be predicted by individual manipulations alone. Likewise\, we ask how stress\, inflammation\, hormones\, and other exposures exacerbate or ameliorate the effect of disease-associated risk factors. We study how genotype-phenotype relationships vary across people and dynamic conditions\, within and between the cell types of the brain. Thus\, rather than just characterize the impact of trait-associated variants\, we seek to uncover modifiers that alter it. Our goal is to decipher the frameworks that buffer genetic risk\, in order to confer biological resilience and promote healthy development. Understanding the basic biology governing the complex interplay between genetic variants and the environment will springboard the development of novel\, personalized approaches to improve health and prevent brain disease
URL:https://nbio.uw.edu/event/wayne-e-crill-endowed-lecture-kristen-brennand-phd-yale-university/
LOCATION:Foege Genome Sciences Auditorium S-060\, 3720 15th Ave NE\, Seattle\, WA\, 98195\, United States
CATEGORIES:Seminar
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ORGANIZER;CN="UW NBIO":MAILTO:nbio@uw.edu
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DTSTART;TZID=America/Los_Angeles:20260611T093000
DTEND;TZID=America/Los_Angeles:20260611T103000
DTSTAMP:20260625T084404
CREATED:20250909T184606Z
LAST-MODIFIED:20260604T165549Z
UID:10000108-1781170200-1781173800@nbio.uw.edu
SUMMARY:NBIO Presents: Kara Marshall\, PhD (Baylor College of Medicine)
DESCRIPTION:Feeling the Force: PIEZO ion channels in interoception\nAbstract:  The Marshall lab studies how mechanosensory molecules and cells—those that sense forces like pressure and stretch—regulate physiology. Inside our bodies\, various organs distend and contract as they perform their functions\, and embedded neurons monitor and transmit the resulting mechanical sensations to the brain to guide the appropriate behaviors. For example\, stretch sensors in the stomach initiate digestion and mediate the sensation of fullness\, and bladder stretch alerts us to find a bathroom. Despite their importance\, the mechanosensory systems that govern these processes are not well understood. We previously have found that the mechanosensory PIEZO ion channels are critical for a number of interoceptive functions\, and we continue using these sensors as genetic handles to understand how mechanosensation contributes to physiology in health and disease
URL:https://nbio.uw.edu/event/nbio-presents-kara-marshall-baylor-college-of-medicine/
LOCATION:Health Sciences G-328
CATEGORIES:Seminar
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ORGANIZER;CN="UW NBIO":MAILTO:nbio@uw.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20260611T150000
DTEND;TZID=America/Los_Angeles:20260611T163000
DTSTAMP:20260625T084404
CREATED:20260601T165847Z
LAST-MODIFIED:20260601T165847Z
UID:10000131-1781190000-1781195400@nbio.uw.edu
SUMMARY:Virginia Merrill Bloedel Hearing Research Center presents: Craig A. Buchman\, MD\, FACS (University of Utah)
DESCRIPTION:Simultaneous Multi-Electrode Recordings Along Human Scala Tympani: Evidence for Level Dependent Coding
URL:https://nbio.uw.edu/event/virginia-merrill-bloedel-hearing-research-center-presents-craig-a-buchman-md-facs-university-of-utah/
LOCATION:Haring Center Auditorium CD 150\, 1701 NE Columbia Ave\, Seattle\, Washington\, 98195\, United States
ATTACH;FMTTYPE=image/jpeg:https://uwnbiooffload.s3.us-west-2.amazonaws.com/wp-content/uploads/2026/06/01095835/buchman.jpg
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BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20260618T093000
DTEND;TZID=America/Los_Angeles:20260618T103000
DTSTAMP:20260625T084404
CREATED:20251126T193440Z
LAST-MODIFIED:20260615T174831Z
UID:10000123-1781775000-1781778600@nbio.uw.edu
SUMMARY:NBIO Presents: Hernandez Moura Silva\, PhD (Ragon Institute of MGH\, MIT and Harvard)
DESCRIPTION:Ironing Out the Ferrostatic Role of Vasculature Associated Macrophages\nIron is an essential micronutrient required by nearly all living organisms\, and maintaining its homeostasis represents a fundamental biological challenge across multiple levels\, from individual cells to entire tissues and the whole organism. We propose that local iron regulation within adipose tissue is centrally coordinated by vasculature-associated macrophages (VAMs)\, a specialized population of resident tissue macrophages closely associated with the vasculature and known to perform key homeostatic functions. While VAMs and other resident tissue macrophages have been historically linked to host defense/innate immunity\, there is a major gap in our understanding of their diverse functions beyond immunity\, and how their dysfunction drives the progression of chronic inflammatory diseases. Gene expression profiling reveals that VAMs express a comprehensive suite of genes involved in iron import\, export\, processing\, and storage. Our data further demonstrate that VAMs are the most efficient cell type within adipose tissue at importing transferrin-bound iron from the circulation and also function as significant intracellular iron reservoirs. Based on these findings\, we demonstrate that VAMs act as central regulators of adipose tissue iron content\, continuously sensing local demand and modulating iron availability to support tissue homeostasis.
URL:https://nbio.uw.edu/event/nbio-presents-hernandez-moura-silva/
LOCATION:Health Sciences G-328
CATEGORIES:Seminar
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ORGANIZER;CN="UW NBIO":MAILTO:nbio@uw.edu
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