BEGIN:VCALENDAR VERSION:2.0 PRODID:-//UW Neurobiology & Biophysics - ECPv6.15.20//NONSGML v1.0//EN CALSCALE:GREGORIAN METHOD:PUBLISH X-WR-CALNAME:UW Neurobiology & Biophysics X-ORIGINAL-URL:https://nbio.uw.edu X-WR-CALDESC:Events for UW Neurobiology & Biophysics REFRESH-INTERVAL;VALUE=DURATION:PT1H X-Robots-Tag:noindex X-PUBLISHED-TTL:PT1H BEGIN:VTIMEZONE TZID:America/Los_Angeles BEGIN:DAYLIGHT TZOFFSETFROM:-0800 TZOFFSETTO:-0700 TZNAME:PDT DTSTART:20250309T100000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0700 TZOFFSETTO:-0800 TZNAME:PST DTSTART:20251102T090000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:-0800 TZOFFSETTO:-0700 TZNAME:PDT DTSTART:20260308T100000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0700 TZOFFSETTO:-0800 TZNAME:PST DTSTART:20261101T090000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:-0800 TZOFFSETTO:-0700 TZNAME:PDT DTSTART:20270314T100000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0700 TZOFFSETTO:-0800 TZNAME:PST DTSTART:20271107T090000 END:STANDARD END:VTIMEZONE BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20260115T093000 DTEND;TZID=America/Los_Angeles:20260115T103000 DTSTAMP:20260503T171534 CREATED:20250909T202623Z LAST-MODIFIED:20260403T164236Z UID:10000090-1768469400-1768473000@nbio.uw.edu SUMMARY:NBIO Presents: Karen Zito\, PhD (University of California Davis) DESCRIPTION:Ion flux-independent NMDAR signaling in bidirectional synaptic plasticity and disease\nNMDA receptors play vital roles in a broad array of essential brain functions\, from synaptic transmission and plasticity to learning and memory. Historically\, the fundamental roles of NMDARs were attributed to their specialized properties of ion flux. More recently\, it has become clear that NMDARs can drive synaptic plasticity in an ion flux-independent manner. I will present recent data that elucidates ion flux-independent NMDAR signaling mechanisms in synaptic plasticity and their physiological consequences in health and disease. \n Health Sciences G328 and Zoom URL:https://nbio.uw.edu/event/nbio-presents-karen-zito-phd-university-of-california-davis/ LOCATION:Health Sciences G-328 CATEGORIES:Seminar ATTACH;FMTTYPE=image/jpeg:https://nbio.uw.edu/wp-content/uploads/2025/07/20220914_september-campus_26-e1760646923422.jpg ORGANIZER;CN="UW NBIO":MAILTO:nbio@uw.edu END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20260122T093000 DTEND;TZID=America/Los_Angeles:20260122T103000 DTSTAMP:20260503T171534 CREATED:20251125T234105Z LAST-MODIFIED:20260403T164310Z UID:10000091-1769074200-1769077800@nbio.uw.edu SUMMARY:NBIO Presents: Jhimmy Talbot (Fred Hutchinson Cancer Research Center) DESCRIPTION:Neural regulation of intestinal immune and absorptive functions\nThe intestinal mucosa serves both as a conduit for the uptake of food-derived nutrients and microbiome-derived metabolites\, and as a barrier that prevents tissue invasion by microorganisms. How the intestine coordinates physiological responses to food consumption to optimize nutrient uptake while maintaining barrier functions remains unclear. My lab’s goal is to develop a comprehensive understanding of how the gut balances these competing metabolic and immune needs. Using genetically modified mouse models we have identified neuronal circuits activated by diet and microbes that coordinate intestinal immunity and host nutrition. Our studies may reveal how changes in diet or the microbiota lead to metabolic dysfunctions and provide insights into how pathogens hijack neurons to facilitate infection. \n Health Science G 328 and on Zoom \n  URL:https://nbio.uw.edu/event/nbio-presents-jhimmy-talbot-fred-hutchinson-cancer-research-center/ LOCATION:Health Sciences G-328 CATEGORIES:Seminar ATTACH;FMTTYPE=image/jpeg:https://nbio.uw.edu/wp-content/uploads/2025/09/jhimmy-talbott.jpeg ORGANIZER;CN="UW NBIO":MAILTO:nbio@uw.edu END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20260128T123000 DTEND;TZID=America/Los_Angeles:20260128T133000 DTSTAMP:20260503T171534 CREATED:20260127T191435Z LAST-MODIFIED:20260127T191512Z UID:10000127-1769603400-1769607000@nbio.uw.edu SUMMARY:CNC Presents: John Widloski\, PhD (Allen Institute for Neural Dynamics) DESCRIPTION:“Fluid Memory: Explorations in hippocampal replay” URL:https://nbio.uw.edu/event/cnc-presents-john-widloski-phd-allen-institute-for-neural-dynamics/ LOCATION:South Campus Center 354\, 1601 NE Columbia Rd\, Seattle\, WA\, 98195\, United States ATTACH;FMTTYPE=image/png:https://nbio.uw.edu/wp-content/uploads/2026/01/Widloski-Poster-e1769541306589.png ORGANIZER;CN="UW Computational Neuroscience Center (CNC)":MAILTO:compneuro@u.washington.edu END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20260204T133000 DTEND;TZID=America/Los_Angeles:20260204T143000 DTSTAMP:20260503T171534 CREATED:20260202T214519Z LAST-MODIFIED:20260403T164403Z UID:10000128-1770211800-1770215400@nbio.uw.edu SUMMARY:CNC Presents: Andrea Stocco\, PhD (UW Psychology) DESCRIPTION:“Computational Phenotyping of Forgetting”\nAbstract: \nForgetting is among the most salient aspects of long-term memory\, yet it is not directly observable\, posing a fundamental challenge for theory. In this talk\, I argue that forgetting is best captured as a latent computational process that can be inferred through computational phenotyping—the use of formal models of cognition to estimate theoretically meaningful parameters from behavior. I will present a series of experiments showing that parameters governing forgetting can be reliably identified at the individual level\, remain stable across time\, and provide diagnostic leverage beyond surface performance measures. \nI will then introduce preliminary EEG and fMRI evidence linking these computational phenotypes to neural dynamics\, providing converging constraints on the underlying mechanisms. Together\, these results inform a long-standing theoretical debate in memory research: whether forgetting reflects the decay of memory representations or a progressive failure of access to otherwise intact representations. More broadly\, this work illustrates how computational phenotyping can serve as a bridge between cognitive theory\,  neural data\, and clinical applications\, enabling stronger tests of mechanistic accounts of memory. URL:https://nbio.uw.edu/event/cnc-presents-andrea-stocco-phd-uw-psychology/ LOCATION:Health Sciences K-069 CATEGORIES:Seminar ATTACH;FMTTYPE=image/png:https://nbio.uw.edu/wp-content/uploads/2026/02/Screenshot-2026-02-02-at-1.43.42-PM-e1770068695445.png ORGANIZER;CN="UW Computational Neuroscience Center (CNC)":MAILTO:compneuro@u.washington.edu END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20260205T190000 DTEND;TZID=America/Los_Angeles:20260205T210000 DTSTAMP:20260503T171534 CREATED:20260107T223800Z LAST-MODIFIED:20260202T214624Z UID:10000126-1770318000-1770325200@nbio.uw.edu SUMMARY:CNC Presents Future Tense: Ryan Calo\, JD (University of Washington School of Law) DESCRIPTION:Future Tense is a series featuring scientists\, thinkers\, and writers discussing the intersections of neuroscience\, artificial intelligence and society. On February 5\, join us for a presentation from UW Law professor Ryan Calo on legal and regulatory approaches to emerging technology.\n\n\n\nLaw and Technology: A Methodical Approach\nTechnology exerts a profound influence on contemporary society\, shaping not just the tools we use but the environments in which we live. Law\, uniquely among social forces\, is positioned to guide and constrain the social fact of technology in the service of human flourishing. Yet\, technology has proven disorienting to law: it presents itself as inevitable\, makes a shell game of human responsibility\, and daunts regulation. Drawing lessons from communities that critically assess emerging technologies\, this book challenges the reflexive acceptance of innovation and critiques the widespread belief that technology is inevitable or ungovernable. It calls for a methodical\, coherent approach to the legal analysis of technology—one capable of resisting technology’s disorienting qualities—thus equipping law to meet the demands of an increasingly technology-mediated world while helping to unify the field of law and technology itself. \nBio\nRyan Calo is the Lane Powell and D. Wayne Gittinger Professor at the University of Washington School of Law. He is a founding co-director (with Batya Friedman and Tadayoshi Kohno) of the interdisciplinary UW Tech Policy Lab and a co-founder (with Chris Coward\, Emma Spiro\, Kate Starbird\, and Jevin West) of the UW Center for an Informed Public. Professor Calo holds a joint appointment at the Information School and an adjunct appointment at the Paul G. Allen School of Computer Science and Engineering. \nProfessor Calo’s research on law and emerging technology appears in leading law reviews (California Law Review\, Columbia Law Review\, Duke Law Journal\, UCLA Law Review\, and University of Chicago Law Review) and technical publications (MIT Press\, Nature\, Artificial Intelligence) and is frequently referenced by the national media. His work has been translated into at least four languages. Professor Calo has testified four times before the United States Senate\, most recently providing witness testimony on July 11\, 2024\, before the United States Senate Committee on Commerce\, Science and Transportation at a hearing titled “The Need to Protect Americans’ Privacy and the AI Accelerant.” Professor Calo stressed the importance of a comprehensive federal privacy law that both protects Americans’ personal privacy and sets guidelines for businesses developing and implementing AI technology. \n\nHealth Sciences Building K-069 URL:https://nbio.uw.edu/event/computational-neuroscience-center-presents-future-tense-ryan-calo-jd-university-of-washington-school-of-law/ LOCATION:Magnuson Health Sciences Center\, University of Washington\, NE Pacific Street\, Seattle\, WA\, 98195\, United States CATEGORIES:Seminar ATTACH;FMTTYPE=image/jpeg:https://nbio.uw.edu/wp-content/uploads/2026/01/calo-ryan_compressed-e1767825449368.jpg ORGANIZER;CN="UW Computational Neuroscience Center (CNC)":MAILTO:compneuro@u.washington.edu END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20260212T093000 DTEND;TZID=America/Los_Angeles:20260212T103000 DTSTAMP:20260503T171534 CREATED:20250909T202446Z LAST-MODIFIED:20260403T164944Z UID:10000093-1770888600-1770892200@nbio.uw.edu SUMMARY:NBIO Presents: Christopher Lapointe\, PhD (Fred Hutchinson Cancer Center) DESCRIPTION:“Dynamic branchpoints regulate selection of translation start codons”\nTo establish the reading frame for protein synthesis\, the human translation initiation machinery must recognize the translation start codon (AUG) with single-nucleotide precision. Yet\, foundational studies in the 1980’s demonstrated that non-AUG start codons (e.g.\, CUG) can also drive protein synthesis. More recent studies indicate widespread and regulated use of non-AUG codons\, with critical roles in the cell cycle\, stress responses\, and disease. I will share how we have been applying single-molecule\, biochemical\, and structural strategies to understand how the initiation machinery balances the need for both precision and flexibility. \n Health Sciences G-328 and Zoom. URL:https://nbio.uw.edu/event/nbio-presents-christopher-lapointe-phd-fred-hutchinson-cancer-center/ LOCATION:Health Sciences G-328 CATEGORIES:Seminar ATTACH;FMTTYPE=image/jpeg:https://nbio.uw.edu/wp-content/uploads/2025/09/Christopher-Lapointe-Crop-scaled-e1770069687899.jpg ORGANIZER;CN="UW NBIO":MAILTO:nbio@uw.edu END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20260219T093000 DTEND;TZID=America/Los_Angeles:20260219T103000 DTSTAMP:20260503T171534 CREATED:20250905T203007Z LAST-MODIFIED:20260403T165129Z UID:10000082-1771493400-1771497000@nbio.uw.edu SUMMARY:NBIO Presents: Dorian McGavern\, PhD (NINDS) DESCRIPTION:“Immunological Defense of Dynamic Vascular Barriers in the CNS”\nAbstract coming soon. \n Health Sciences G328 and Zoom URL:https://nbio.uw.edu/event/nbio-presents-dorian-mcgavern-phd-national-institute-of-neurological-disorders-and-stroke/ LOCATION:Health Sciences G-328 CATEGORIES:Seminar ATTACH;FMTTYPE=image/jpeg:https://nbio.uw.edu/wp-content/uploads/2025/09/AdobeStock_1594512976-scaled-e1764183889902.jpeg ORGANIZER;CN="UW NBIO":MAILTO:nbio@uw.edu END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20260226T093000 DTEND;TZID=America/Los_Angeles:20260226T103000 DTSTAMP:20260503T171534 CREATED:20251126T190044Z LAST-MODIFIED:20260403T165224Z UID:10000095-1772098200-1772101800@nbio.uw.edu SUMMARY:NBIO Presents: Christopher Fortenbach\, MD\, PhD\, (University of Washington\, Department of Ophthalmology) DESCRIPTION:Photochemical Vision Restoration in Outer Retinal Degeneration \nAge-related macular degeneration and retinitis pigmentosa are the most common causes of blindness in high-income countries. These forms of outer retinal degeneration result in progressive loss of photoreceptor cells while the inner retina largely remains structurally intact. While current therapies to address this vision loss are limited\, a promising strategy involves the intravitreal injection of small molecules known as photoswitches. These photochemical ligands restore light-mediated responses by binding to surviving inner retinal neurons and blocking ion channels in a conformation-dependent manner. Upon absorbing light of a particular wavelength\, they undergo a cis-trans isomerization\, resulting in a light-dependent electrical response that can be conveyed to downstream neurons. Unlike surgical implants or viral-mediated gene therapies\, photoswitches are titratable and upgradable as newer therapies become available. My laboratory develops and studies a novel class of photoswitches designed to target upstream retinal neurons and restore retinal signaling. We investigate the mechanisms by which these ligands act on the retina using a combination of electrophysiological techniques\, and we quantify the retina’s encoding capacity in response to visual stimuli. Ultimately\, by improving our understanding of how photoswitch structure influences the restoration of retinal signaling\, we aim to design better therapies that more closely mimic native visual signaling.  URL:https://nbio.uw.edu/event/nbio-presents-christopher-fortenbach-md-phd-university-of-washington-department-of-ophthalmology/ LOCATION:Health Sciences G-328 CATEGORIES:Seminar ATTACH;FMTTYPE=image/png:https://nbio.uw.edu/wp-content/uploads/2025/11/Screenshot-2025-11-26-at-11.02.19-AM-e1764183770851.png ORGANIZER;CN="UW NBIO":MAILTO:nbio@uw.edu END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20260305T093000 DTEND;TZID=America/Los_Angeles:20260305T103000 DTSTAMP:20260503T171534 CREATED:20250909T202240Z LAST-MODIFIED:20260403T165258Z UID:10000096-1772703000-1772706600@nbio.uw.edu SUMMARY:NBIO Presents: Travis Rotterman\, PhD (Boston University) DESCRIPTION:Spinal motor circuits reorganization in response to peripheral neuropathy\nPeripheral neuropathy encompasses a constellation of injuries and diseases that lead to peripheral axon degeneration\, a process commonly referred to as Wallerian degeneration. This pathological axonal loss disrupts sensory-motor integration and gives rise to an array of debilitating symptoms such interjoint discoordination\, postural instability\, and ataxia. In this talk I will present several ongoing projects investigating how peripheral nerve damage drives reorganization of spinal motor circuits\, as well as strategies we are exploring to rescue synaptic connectivity and ultimately improving functional outcomes. \n Health Sciences G328 and Zoom URL:https://nbio.uw.edu/event/nbio-presents-travis-rotterman-boston-university/ LOCATION:Health Sciences G-328 CATEGORIES:Seminar ATTACH;FMTTYPE=image/jpeg:https://nbio.uw.edu/wp-content/uploads/2025/09/rotterman-1441x2048-1-e1772214677717.jpg ORGANIZER;CN="UW NBIO":MAILTO:nbio@uw.edu END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20260312T093000 DTEND;TZID=America/Los_Angeles:20260312T103000 DTSTAMP:20260503T171534 CREATED:20250909T202152Z LAST-MODIFIED:20260403T165336Z UID:10000097-1773307800-1773311400@nbio.uw.edu SUMMARY:NBIO Presents: Rebecca Shansky\, PhD (Northeastern University) DESCRIPTION:Prefrontal Circuit Mechanisms Driving Sex Differences in Defensive Responding\nMy lab works to identify sex differences in brain organization that underlie variation in defensive responding. We find that in Pavlovian fear conditioning paradigms\, females are more likely than males to engage active\, escape-like conditioned responses (“darting”) that may be linked to pain processing cortical circuitry. Recently\, our work has focused on connectivity between the anterior cingulate and infralimbic regions of the prefrontal cortex and longitudinal columns of the periaqueductal gray. We use a combination of tract tracing\, immunohistological\, chemogenetic\, and RNAscope techniques to map gene expression and manipulate activity in these circuits\, finding novel sex differences in structure and function as they relate to behavioral outcomes.  \n Health Sciences G328 and Zoom URL:https://nbio.uw.edu/event/nbio-presents-rebecca-shansky-phd-northeastern-university/ LOCATION:Health Sciences G-328 CATEGORIES:Seminar ATTACH;FMTTYPE=image/jpeg:https://nbio.uw.edu/wp-content/uploads/2025/09/shansky_rebecca-e1772214337176.jpg ORGANIZER;CN="UW NBIO":MAILTO:nbio@uw.edu END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20260319T093000 DTEND;TZID=America/Los_Angeles:20260319T103000 DTSTAMP:20260503T171534 CREATED:20260205T190422Z LAST-MODIFIED:20260403T165410Z UID:10000098-1773912600-1773916200@nbio.uw.edu SUMMARY:NBIO Presents: Jayeeta Basu\, PhD (New York University) DESCRIPTION:Cortico-Hippocampal Circuit Interactions in Shaping Learning and Memory Representations\nFlexibility and stability of neuronal ensembles are crucial features of brain function. Little is known about how these properties of local circuits are influenced by long-range inputs. We show\, in mice\, that lateral entorhinal cortex glutamatergic  and GABAergic  projections to CA3 recruit specific microcircuits that conjunctively provide stability to neuronal ensembles\, thereby supporting learning. Furthermore\, circuit mapping and manipulations of hippocampal back-projections to entorhinal cortex in mice show anatomically and functionally distinct hippocampal feedback pathways to deep and superficial layers of the medial entorhinal cortex that differentially modulate excitation-inhibition dynamics\, plasticity\, and novelty driven behavioral output. \n  \n Health Sciences G 328 and Zoom URL:https://nbio.uw.edu/event/jayeeta-basu-new-york-university/ LOCATION:Health Sciences G-328 CATEGORIES:Seminar ATTACH;FMTTYPE=image/jpeg:https://nbio.uw.edu/wp-content/uploads/2026/02/basuj01-hero-e1770318502144.jpg ORGANIZER;CN="UW NBIO":MAILTO:nbio@uw.edu END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20260407T160000 DTEND;TZID=America/Los_Angeles:20260407T170000 DTSTAMP:20260503T171534 CREATED:20251016T203923Z LAST-MODIFIED:20260403T165516Z UID:10000099-1775577600-1775581200@nbio.uw.edu SUMMARY:Lamport Lecture: Kathleen Cullen\, PhD (Johns Hopkins University) DESCRIPTION:Predictive Neural Computations for Self-Motion\nHow does the brain distinguish self-generated motion from motion imposed by the external world? In this talk\, I will describe how predictive neural computations shape sensory processing during natural self-motion. Using a combination of systems neurophysiology\, computational modeling\, and behavior\, our work focuses on vestibular\, cerebellar\, and thalamocortical circuits operating in closed-loop interactions with the environment. I will show how internal predictions dynamically modulate neural responses\, suppressing predictable self-generated input while preserving sensitivity to unexpected motion. I will conclude by discussing implications for perception\, motor control\, and neuroprosthetic design. \nDr. Kathleen Cullen\, PhD is a professor of Neuroscience\, Otolaryngology\, and Biomedical Engineering at John Hopkins University. \nhttps://www.bme.jhu.edu/people/faculty/kathleen-cullen/ URL:https://nbio.uw.edu/event/lamport-lecture-kathleen-cullen-johns-hopkins-university/ LOCATION:Foege Genome Sciences Auditorium S-060\, 3720 15th Ave NE\, Seattle\, WA\, 98195\, United States CATEGORIES:Seminar ATTACH;FMTTYPE=image/jpeg:https://nbio.uw.edu/wp-content/uploads/2025/10/Cullen-e1772487531266.jpeg ORGANIZER;CN="UW NBIO":MAILTO:nbio@uw.edu END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20260416T093000 DTEND;TZID=America/Los_Angeles:20260416T103000 DTSTAMP:20260503T171534 CREATED:20260403T164823Z LAST-MODIFIED:20260403T203729Z UID:10000092-1776331800-1776335400@nbio.uw.edu SUMMARY:NBIO Presents: Asim Iqbal\, PhD\, (Tibbling Technologies) DESCRIPTION:NeuroAI for Generalised Neurological Discovery\nThe mammalian brain exhibits a remarkable ability to generalize to novel tasks\, sensory modalities\, and environments using limited data and high energy efficiency. In contrast\, current AI systems rely on large-scale datasets\, operate within fixed input modalities\, and fail to build robust cross-domain representations\, resulting in poor generalization and performance degradation when adapting to new tasks. In this seminar\, I will introduce a NeuroAI architecture grounded in principles of neural computation\, designed to identify and embed these mechanisms within multimodal transformer models for neuroscientific applications. This architecture supports few-shot generalization across a range of brain disorders\, enabling applications in mechanistic discovery\, personalized rehabilitation\, and targeted therapeutic strategies URL:https://nbio.uw.edu/event/nbio-presents-asim-iqbal-phd-founder-ceo-tibbling-technologies/ LOCATION:Health Sciences G-328 CATEGORIES:Seminar ATTACH;FMTTYPE=image/jpeg:https://uwnbiooffload.s3.us-west-2.amazonaws.com/wp-content/uploads/2026/04/03133639/AI_mugshot_small-e1775248627438.jpg ORGANIZER;CN="UW NBIO":MAILTO:nbio@uw.edu END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20260423T093000 DTEND;TZID=America/Los_Angeles:20260423T103000 DTSTAMP:20260503T171534 CREATED:20250909T201617Z LAST-MODIFIED:20260403T204634Z UID:10000101-1776936600-1776940200@nbio.uw.edu SUMMARY:NBIO Presents: Karina Cramer\, PhD (UC Irvine) DESCRIPTION:Assembly of Auditory Brainstem Circuitry: The Roles of Microglia\nNeural circuits in the auditory brainstem require precise connections with highly specialized functions. How are these pathways assembled during development? We have explored the functions of microglia\, the brain’s resident immune cells. These cells enter the auditory nuclei early in development and help shape the mature synaptic connections. Removal of microglia results in impaired development and auditory function\, but microglial repopulation can restore these processes. We are looking into the mechanisms that microglia use to shape auditory circuitry. URL:https://nbio.uw.edu/event/nbio-presents-karina-cramer-phd-uc-irvine/ LOCATION:Health Sciences G-328 CATEGORIES:Seminar ATTACH;FMTTYPE=image/png:https://uwnbiooffload.s3.us-west-2.amazonaws.com/wp-content/uploads/2025/09/03134610/Untitled-design9.png ORGANIZER;CN="UW NBIO":MAILTO:nbio@uw.edu END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20260430T093000 DTEND;TZID=America/Los_Angeles:20260430T103000 DTSTAMP:20260503T171534 CREATED:20250909T201438Z LAST-MODIFIED:20260403T204817Z UID:10000102-1777541400-1777545000@nbio.uw.edu SUMMARY:NBIO Presents: Mariko Bennett\, MD\, PhD (University of Pennsylvania) DESCRIPTION:Living Drugs: Targeting microglia for neurotherapies\nMicroglia are the brain’s parenchymal macrophages\, operating at the interface of sentinel sensing and effector function. As both sculptors and defenders of neural circuits\, they offer an exceptional therapeutic opportunity. This talk will explore microglial form and function\, their contributions to rare neurological diseases\, and how emerging biology can be leveraged to develop microglia-targeted therapeutic strategies. URL:https://nbio.uw.edu/event/nbio-presents-mariko-bennett-md-phd-university-of-pennsylvania/ LOCATION:Health Sciences G-328 CATEGORIES:Seminar ATTACH;FMTTYPE=image/png:https://uwnbiooffload.s3.us-west-2.amazonaws.com/wp-content/uploads/2025/09/03134734/Untitled-design10-e1775249280109.png ORGANIZER;CN="UW NBIO":MAILTO:nbio@uw.edu END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20260507T093000 DTEND;TZID=America/Los_Angeles:20260507T103000 DTSTAMP:20260503T171534 CREATED:20251126T191257Z LAST-MODIFIED:20260428T183205Z UID:10000103-1778146200-1778149800@nbio.uw.edu SUMMARY:NBIO Presents: Jean-Claude Béïque\, PhD (University of Ottawa) DESCRIPTION:A tale of serotonin’s value: From release dynamics to behavioral regulation URL:https://nbio.uw.edu/event/nbio-presents-jean-claude-beique-phd-university-of-ottawa/ LOCATION:Health Sciences G-328 CATEGORIES:Seminar ATTACH;FMTTYPE=image/webp:https://nbio.uw.edu/wp-content/uploads/2025/09/jean-claude-e1764184369825.webp ORGANIZER;CN="UW NBIO":MAILTO:nbio@uw.edu END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20260514T093000 DTEND;TZID=America/Los_Angeles:20260514T103000 DTSTAMP:20260503T171534 CREATED:20250909T201317Z LAST-MODIFIED:20260403T172409Z UID:10000104-1778751000-1778754600@nbio.uw.edu SUMMARY:NBIO Presents: Nanthia Suthana\, PhD (Duke University) DESCRIPTION:Neural Dynamics of Human Memory in Naturalistic Environments\nUnderstanding how the human brain supports memory in real-world settings remains a central challenge in neuroscience. In this talk\, I will present work combining intracranial recordings\, wearable sensing\, and immersive paradigms to study memory during naturalistic behavior. We recorded activity from the human medial temporal lobe while participants navigated real and virtual environments alongside measurements of eye movements and behavior. Neural activity exhibited structured dynamics linked to memory-guided exploration\, including coordination with eye movements and representations of position along remembered routes\, with consistent organization across real and imagined navigation. Extending this framework\, I will present findings from naturalistic fear conditioning paradigms\, demonstrating how memory-related neural dynamics are shaped by emotional learning. I will discuss how these insights can be leveraged to decode and modulate maladaptive memory processes\, with implications for developing closed-loop neurostimulation approaches for disorders such as post-traumatic stress disorder. URL:https://nbio.uw.edu/event/nbio-presents-nanthia-suthana-phd-duke-university/ LOCATION:Health Sciences G-328 CATEGORIES:Seminar ATTACH;FMTTYPE=image/webp:https://uwnbiooffload.s3.us-west-2.amazonaws.com/wp-content/uploads/2025/09/03102039/Nanthia_Suthana-e1775237036336.webp ORGANIZER;CN="UW NBIO":MAILTO:nbio@uw.edu END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20260521T093000 DTEND;TZID=America/Los_Angeles:20260521T103000 DTSTAMP:20260503T171534 CREATED:20251016T204603Z LAST-MODIFIED:20260403T172744Z UID:10000118-1779355800-1779359400@nbio.uw.edu SUMMARY:NBIO Presents: Jason Shepherd\, PhD (University of Utah) DESCRIPTION:Seminar information coming soon! \n Health Sciences G328 and Zoom URL:https://nbio.uw.edu/event/nbio-presents-jason-shepherd-phd-university-of-utah/ LOCATION:Health Sciences G-328 CATEGORIES:Seminar ATTACH;FMTTYPE=image/jpeg:https://uwnbiooffload.s3.us-west-2.amazonaws.com/wp-content/uploads/2025/10/03102446/Shepherd_Jason_Headshot-2025-e1775237120540.jpg ORGANIZER;CN="UW NBIO":MAILTO:nbio@uw.edu END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20260528T093000 DTEND;TZID=America/Los_Angeles:20260528T103000 DTSTAMP:20260503T171534 CREATED:20250909T201041Z LAST-MODIFIED:20260403T173132Z UID:10000106-1779960600-1779964200@nbio.uw.edu SUMMARY:NBIO Presents: Marius Pachitariu (Janelia Research Campus) DESCRIPTION:Linking neural representations to behavior using generalization\nSensory-guided decisions are the result of sensorimotor transformations across many brain areas. Recent studies have localized the motor components of these transformations using correlations between brain-wide neural activity and behavior. It has been more difficult to localize sensory computations with the same approach\, as it requires pushing animal performance close to psychophysical thresholds\, which is typically not feasible. Here we developed a new approach for linking sensory computations to behavior by training mice to discriminate between two stimuli and testing their responses to new stimuli. We then calculated the similarity of neural representations between train and test stimuli\, using recordings of over 50\,000 simultaneously-recorded neurons from 9 primary and higher-order visual areas (HVAs) and across cortical depths. We found that neural discrimination on the test images but not the train images correlated with the behavioral discrimination of the animals\, across a large number of stimulus pairs and animals. The link between neural and behavioral performance was highest in the medial HVAs\, suggesting this region as a critical component of sensory transformations and generalization. URL:https://nbio.uw.edu/event/nbio-presents-marius-pachitariu-janelia-research-campus/ LOCATION:Health Sciences G-328 CATEGORIES:Seminar ATTACH;FMTTYPE=image/jpeg:https://nbio.uw.edu/wp-content/uploads/2025/03/20240420_Admitted-Student-Day_002-e1764184928561.jpeg ORGANIZER;CN="UW NBIO":MAILTO:nbio@uw.edu END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20260609T000000 DTEND;TZID=America/Los_Angeles:20260609T235959 DTSTAMP:20260503T171534 CREATED:20251126T192949Z LAST-MODIFIED:20251126T192949Z UID:10000119-1780963200-1781049599@nbio.uw.edu SUMMARY:Wayne E. Crill Endowed Lecture: Kristen Brennand\, PhD (Yale University) DESCRIPTION:Title and abstract coming soon! URL:https://nbio.uw.edu/event/wayne-e-crill-endowed-lecture-kristen-brennand-phd-yale-university/ LOCATION:TBA CATEGORIES:Seminar ATTACH;FMTTYPE=image/webp:https://nbio.uw.edu/wp-content/uploads/2025/11/brennand-e1764185349396.webp END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20260611T093000 DTEND;TZID=America/Los_Angeles:20260611T103000 DTSTAMP:20260503T171534 CREATED:20250909T184606Z LAST-MODIFIED:20260403T184125Z UID:10000108-1781170200-1781173800@nbio.uw.edu SUMMARY:NBIO Presents: Kara Marshall\, PhD (Baylor College of Medicine) DESCRIPTION:Seminar Information coming soon! URL:https://nbio.uw.edu/event/nbio-presents-kara-marshall-baylor-college-of-medicine/ LOCATION:Health Sciences G-328 CATEGORIES:Seminar ATTACH;FMTTYPE=image/jpeg:https://nbio.uw.edu/wp-content/uploads/2025/10/20231114_November-Campus-Fall-Colors_1126-e1764185509834.jpg ORGANIZER;CN="UW NBIO":MAILTO:nbio@uw.edu END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20260618T093000 DTEND;TZID=America/Los_Angeles:20260618T103000 DTSTAMP:20260503T171534 CREATED:20251126T193440Z LAST-MODIFIED:20260403T184323Z UID:10000123-1781775000-1781778600@nbio.uw.edu SUMMARY:NBIO Presents: Hernandez Moura Silva\, PhD (Ragon Institute of MGH\, MIT and Harvard) DESCRIPTION:Ironing Out the Ferrostatic Role of Vasculature Associated Macrophages\nIron is an essential micronutrient required by nearly all living organisms\, and maintaining its homeostasis represents a fundamental biological challenge across multiple levels\, from individual cells to entire tissues and the whole organism. We propose that local iron regulation within adipose tissue is centrally coordinated by vasculature-associated\nmacrophages (VAMs)\, a specialized population of resident tissue macrophages closely associated with the vasculature and known to perform key homeostatic functions. While VAMs and other resident tissue macrophages have been historically linked to host defense/innate immunity\, there is a major gap in our understanding of their diverse functions beyond immunity\, and how their dysfunction drives the progression of chronic inflammatory diseases. Gene expression profiling reveals that VAMs express a comprehensive suite of genes involved in iron import\, export\, processing\, and storage. Our data further demonstrate that VAMs are the most efficient cell type within adipose tissue at importing transferrin-bound iron from the circulation and also function as significant intracellular iron reservoirs. Based on these findings\, we demostrate that VAMs act as central regulators of adipose tissue iron content\, continuously sensing local demand and modulating iron availability to support tissue homeostasis. URL:https://nbio.uw.edu/event/nbio-presents-hernandez-moura-silva/ LOCATION:Health Sciences G-328 CATEGORIES:Seminar ATTACH;FMTTYPE=image/jpeg:https://nbio.uw.edu/wp-content/uploads/2025/11/Hernandez_Moura_Silva-Big-e1764185628791.jpg ORGANIZER;CN="UW NBIO":MAILTO:nbio@uw.edu END:VEVENT END:VCALENDAR