BEGIN:VCALENDAR VERSION:2.0 PRODID:-//UW Neurobiology & Biophysics - ECPv6.15.20//NONSGML v1.0//EN CALSCALE:GREGORIAN METHOD:PUBLISH X-WR-CALNAME:UW Neurobiology & Biophysics X-ORIGINAL-URL:https://nbio.uw.edu X-WR-CALDESC:Events for UW Neurobiology & Biophysics REFRESH-INTERVAL;VALUE=DURATION:PT1H X-Robots-Tag:noindex X-PUBLISHED-TTL:PT1H BEGIN:VTIMEZONE TZID:America/Los_Angeles BEGIN:DAYLIGHT TZOFFSETFROM:-0800 TZOFFSETTO:-0700 TZNAME:PDT DTSTART:20240310T100000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0700 TZOFFSETTO:-0800 TZNAME:PST DTSTART:20241103T090000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:-0800 TZOFFSETTO:-0700 TZNAME:PDT DTSTART:20250309T100000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0700 TZOFFSETTO:-0800 TZNAME:PST DTSTART:20251102T090000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:-0800 TZOFFSETTO:-0700 TZNAME:PDT DTSTART:20260308T100000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0700 TZOFFSETTO:-0800 TZNAME:PST DTSTART:20261101T090000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:-0800 TZOFFSETTO:-0700 TZNAME:PDT DTSTART:20270314T100000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0700 TZOFFSETTO:-0800 TZNAME:PST DTSTART:20271107T090000 END:STANDARD END:VTIMEZONE BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20260122T093000 DTEND;TZID=America/Los_Angeles:20260122T103000 DTSTAMP:20260504T132829 CREATED:20251125T234105Z LAST-MODIFIED:20260403T164310Z UID:10000091-1769074200-1769077800@nbio.uw.edu SUMMARY:NBIO Presents: Jhimmy Talbot (Fred Hutchinson Cancer Research Center) DESCRIPTION:Neural regulation of intestinal immune and absorptive functions\nThe intestinal mucosa serves both as a conduit for the uptake of food-derived nutrients and microbiome-derived metabolites\, and as a barrier that prevents tissue invasion by microorganisms. How the intestine coordinates physiological responses to food consumption to optimize nutrient uptake while maintaining barrier functions remains unclear. My lab’s goal is to develop a comprehensive understanding of how the gut balances these competing metabolic and immune needs. Using genetically modified mouse models we have identified neuronal circuits activated by diet and microbes that coordinate intestinal immunity and host nutrition. Our studies may reveal how changes in diet or the microbiota lead to metabolic dysfunctions and provide insights into how pathogens hijack neurons to facilitate infection. \n Health Science G 328 and on Zoom \n  URL:https://nbio.uw.edu/event/nbio-presents-jhimmy-talbot-fred-hutchinson-cancer-research-center/ LOCATION:Health Sciences G-328 CATEGORIES:Seminar ATTACH;FMTTYPE=image/jpeg:https://nbio.uw.edu/wp-content/uploads/2025/09/jhimmy-talbott.jpeg ORGANIZER;CN="UW NBIO":MAILTO:nbio@uw.edu END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20260115T093000 DTEND;TZID=America/Los_Angeles:20260115T103000 DTSTAMP:20260504T132829 CREATED:20250909T202623Z LAST-MODIFIED:20260403T164236Z UID:10000090-1768469400-1768473000@nbio.uw.edu SUMMARY:NBIO Presents: Karen Zito\, PhD (University of California Davis) DESCRIPTION:Ion flux-independent NMDAR signaling in bidirectional synaptic plasticity and disease\nNMDA receptors play vital roles in a broad array of essential brain functions\, from synaptic transmission and plasticity to learning and memory. Historically\, the fundamental roles of NMDARs were attributed to their specialized properties of ion flux. More recently\, it has become clear that NMDARs can drive synaptic plasticity in an ion flux-independent manner. I will present recent data that elucidates ion flux-independent NMDAR signaling mechanisms in synaptic plasticity and their physiological consequences in health and disease. \n Health Sciences G328 and Zoom URL:https://nbio.uw.edu/event/nbio-presents-karen-zito-phd-university-of-california-davis/ LOCATION:Health Sciences G-328 CATEGORIES:Seminar ATTACH;FMTTYPE=image/jpeg:https://nbio.uw.edu/wp-content/uploads/2025/07/20220914_september-campus_26-e1760646923422.jpg ORGANIZER;CN="UW NBIO":MAILTO:nbio@uw.edu END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20251211T093000 DTEND;TZID=America/Los_Angeles:20251211T103000 DTSTAMP:20260504T132829 CREATED:20250905T214717Z LAST-MODIFIED:20260403T164120Z UID:10000086-1765445400-1765449000@nbio.uw.edu SUMMARY:NBIO Presents: Xiaoyin Chen\, PhD (Allen Institute) DESCRIPTION:Understanding brain variations using scalable barcoded connectomics and spatiomics\nHumans and other animals exhibit a wide range of behaviors that are both species-specific and variable within a species. Both types of behavioral variations are enabled by genetic\, molecular\, and circuit variations in the brain. Mapping and comparing brain-wide variations at cellular resolution across a population\, however\, remains a tremendous challenge. My lab aims to solve this challenge by developing in situ sequencing and barcoded connectomics tools. These tools are scalable to brain-wide interrogation across populations and sufficiently low-cost to be applied by individual labs\, and allow us to understand molecular and circuit variations with unprecedented details. In this talk\, I will discuss three related studies in which we use these approaches to reveal how the visual cortex and thalamus develop and adapt from mouse to marmoset and macaque. Finally\, I will discuss preliminary data that aim to reveal how individual variations impact brain-wide organization at the molecular level. \n Health Sciences G328 and Zoom URL:https://nbio.uw.edu/event/nbio-presents-xiaoyin-chen-allen-institute-2/ LOCATION:Health Sciences G-328 CATEGORIES:Seminar ATTACH;FMTTYPE=image/jpeg:https://nbio.uw.edu/wp-content/uploads/2025/09/Xiaoyin_Chen_SQUARE-e1757108830744.jpg ORGANIZER;CN="UW NBIO":MAILTO:nbio@uw.edu END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20251204T190000 DTEND;TZID=America/Los_Angeles:20251204T200000 DTSTAMP:20260504T132829 CREATED:20250923T211409Z LAST-MODIFIED:20260311T174439Z UID:10000113-1764874800-1764878400@nbio.uw.edu SUMMARY:Neuroscience\, AI\, and Society: Cory Doctorow "The Reverse-Centaur’s Guide to Criticizing AI" DESCRIPTION:“The Reverse-Centaur’s Guide to Criticizing AI”\nAI can’t do your job\, but an AI salesman can convince your boss to fire you and replace you with an AI that fails to do your job. Being a smart AI critic requires that you distinguish between these two cases\, because otherwise\, you’re just gonna help that fast-talking sales person to put you on the breadline and screw over everyone who relies on your work. \nBio: Cory Doctorow (craphound.com) is a science fiction author\, activist\, and journalist. He is the author of dozens of books\, most recently ENSHITTIFICATION: WHY EVERYTHING SUDDENLY GOT WORSE AND WHAT TO DO ABOUT IT (nonfiction); and the novels PICKS AND SHOVELS and THE BEZZLE (follow-ups to RED TEAM BLUES). Other notable books include the solarpunk novels WALKAWAY and THE LOST CAUSE; the tech policy books THE INTERNET CON and CHOKEPOINT CAPITALISM; and the internationally bestselling YA LITTLE BROTHER series; and the picture book POESY THE MONSTER SLAYER. He maintains a daily blog at Pluralistic.net. He works for the Electronic Frontier Foundation\, is an AD White Professor at Cornell University; an MIT Media Lab Research Affiliate; a Visiting Professor of Computer Science at Open University; a Visiting Professor of Practice at the University of North Carolina’s School of Library and Information Science. He co-founded the UK Open Rights Group. Born in Toronto\, Canada\, he now lives in Los Angeles. In 2020\, he was inducted into the Canadian Science Fiction and Fantasy Hall of Fame. In 2022\, he earned the Sir Arthur Clarke Imagination in Service to Society Awardee for lifetime achievement. In 2024\, the Media Ecology Association awarded him the Neil Postman Award for Career Achievement in Public Intellectual Activity. York University (Canada) made him an Honourary Doctor of Laws; and the Open University (UK) made him an Honourary Doctor of Computer Science. \nAccessibility questions: Contact: cncadmin@uw.edu URL:https://nbio.uw.edu/event/neuroscience-ai-and-society-cory-doctorow-the-reverse-centaurs-guide-to-criticizing-ai/ LOCATION:Samuel E. Kelly Ethnic Cultural Center\, 3931 Brooklyn Ave NE\, Seattle\, WA\, 98105\, United States CATEGORIES:Seminar ATTACH;FMTTYPE=image/png:https://nbio.uw.edu/wp-content/uploads/2025/09/Screenshot-2025-09-23-at-2.12.12-PM-e1758661990183.png ORGANIZER;CN="UW Computational Neuroscience Center (CNC)":MAILTO:compneuro@u.washington.edu END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20251204T093000 DTEND;TZID=America/Los_Angeles:20251204T103000 DTSTAMP:20260504T132829 CREATED:20250905T214401Z LAST-MODIFIED:20260403T163938Z UID:10000085-1764840600-1764844200@nbio.uw.edu SUMMARY:NBIO Presents: Arif Hamid\, PhD (University of Minnesota Twin Cities) DESCRIPTION:On the Principles of Dopamine Release in Dorsal Striatum\nIn this talk\, I will present evidence that dopamine (DA) release across the striatum unfolds not as a global broadcast but as structured spatiotemporal waves that tailor reward signals to the computational specialties of distinct frontostriatal circuits. I will argue that these waves resolve a key spatiotemporal credit assignment problem by vector-weighting regional decision signals to facilitate a dynamic reprioritization of policy gating. I will outline our recent analysis of fundamental activational principles\, demonstrating that DA fluctuations follow lawful\, linear oscillatory dynamics captured by a generalized DA wave equation\, and provide empirical evidence for circuit interactions that generate\, propagate\, and constrain these DA activity primitives. Together\, our studies provide an empirically informed revision of an enduring “global broadcast” hypothesis about DA-RPE signals\, clarifying the circuit and dynamical mechanisms underlying DA’s role in reinforcement learning. \n Health Sciences G328 and Zoom URL:https://nbio.uw.edu/event/nbio-presents-arif-hamid-university-of-minnesota-twin-cities-2/ LOCATION:Health Sciences G-328 CATEGORIES:Seminar ATTACH;FMTTYPE=image/jpeg:https://nbio.uw.edu/wp-content/uploads/2025/09/ArifHamid-Headshot2-e1763760408446.jpg ORGANIZER;CN="UW NBIO":MAILTO:nbio@uw.edu END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20251120T093000 DTEND;TZID=America/Los_Angeles:20251120T103000 DTSTAMP:20260504T132829 CREATED:20250905T214302Z LAST-MODIFIED:20260403T163807Z UID:10000088-1763631000-1763634600@nbio.uw.edu SUMMARY:NBIO Presents: Amy Arnsten\, PhD (Yale University) DESCRIPTION:“Dynamic Network Connectivity: The unusual molecular regulation of dorsolateral prefrontal cortex confers vulnerability to cognitive disorders”\nThe dorsolateral prefrontal cortex (dlPFC) subserves high order cognitive functions such as working memory and abstract thought and the top-down control of attention\, action and emotion. However\, the dlPFC is remarkably fragile\, impaired by fatigue\, stress\, aging and inflammation\, and is dysfunctional in most cognitive disorders. Arnsten’s lab has discovered the unusual molecular mechanisms that govern these circuits\, which are essential for generating and sustaining representations in working memory and for coordinating cognitive state with arousal state. However\, these same mechanisms can lead to atrophy and tau pathology when dysregulated by stress and/or inflammation. Knowledge of these mechanisms has led to treatments for cognitive disorders in patients. \n Health Sciences G328 and Zoom URL:https://nbio.uw.edu/event/nbio-presents-amy-arnsten-yale-university/ LOCATION:Health Sciences G-328 CATEGORIES:Seminar ATTACH;FMTTYPE=image/jpeg:https://nbio.uw.edu/wp-content/uploads/2025/09/AFTA-photo-e1760644726122.jpeg ORGANIZER;CN="UW NBIO":MAILTO:nbio@uw.edu END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20251113T093000 DTEND;TZID=America/Los_Angeles:20251113T103000 DTSTAMP:20260504T132829 CREATED:20251027T221535Z LAST-MODIFIED:20260403T163727Z UID:10000121-1763026200-1763029800@nbio.uw.edu SUMMARY:NBIO Presents: Dana Miller\, PhD (University of Washington) DESCRIPTION:“Genetic and epigenetic regulation of H2S homeostasis in C. elegans”\nHydrogen sulfide (H2S) was once known primarily as a toxic gas with the smell of rotten eggs. However\, H2S also has many roles as a cellular messenger that can promote survival in stressful conditions. Both endogenously produced and exogenously supplied H2S protect against cellular damage and death associated with ischemia/reperfusion injury in mammals. We use C. elegans to explore mechanisms of beneficial and toxic effects of H2S in animals. We have shown that C. elegans grown in 50 ppm H2S are long-lived and resistant to hypoxia-induced disruption of protein homeostasis\, and that the early transcriptional response to H2S requires the C. elegans orthologue of the hypoxia-inducible transcription factor\, hif-1. HIF-1 promotes survival in H2S\, at least in part\, by upregulating expression of sqrd-1\, which encodes the sulfide-quinone oxidoreductase. SQRD-1 catalyzes the first step in the mitochondrial oxidation of H2S\, the only known cellular pathway for H2S catabolism. We have found that exposure to H2S activates an epigenetic response that forms a transcriptional memory that enables the animals to survive subsequent exposure to otherwise lethal H2S. We have also identified a protein\, RHY-1\, that can promote H2S tolerance even in the absence of the hif-1-mediated transcriptional response or the sqrd-1-mediated H2S oxidation. RHY-1 is an integral- membrane ER protein with predicted acyltransferase (ACYL3) activity. The ACYL3 family is large and conserved across species from bacteria to primates\, but the function of these enzymes is largely unstudied. We identified a novel methyltransferase\, RIPS-1\, that is specifically required for RHY-1 to promote survival in H2S using biotinylation by antibody recognition (BAR). Our preliminary genetic evidence suggests that cholinergic signaling is required for the protective effects of RHY-1 expression in H2S. \nIn Health Sciences G-328 and on Zoom URL:https://nbio.uw.edu/event/nbio-presents-dana-miller-phd-university-of-washington/ LOCATION:Health Sciences G-328 CATEGORIES:Seminar ATTACH;FMTTYPE=image/jpeg:https://nbio.uw.edu/wp-content/uploads/2025/10/20231114_November-Campus-Fall-Colors_1126-e1764185509834.jpg ORGANIZER;CN="UW NBIO":MAILTO:nbio@uw.edu END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20251030T093000 DTEND;TZID=America/Los_Angeles:20251030T103000 DTSTAMP:20260504T132829 CREATED:20250905T211255Z LAST-MODIFIED:20260403T163634Z UID:10000087-1761816600-1761820200@nbio.uw.edu SUMMARY:NBIO Presents: Ted Erclik\, PhD (University of Toronto Mississauga) DESCRIPTION:Seminar information coming soon! \n Health Sciences G328 and Zoom URL:https://nbio.uw.edu/event/nbio-presents-ted-erclik-phd-university-of-toronto-mississauga/ LOCATION:Health Sciences G-328 CATEGORIES:Seminar ATTACH;FMTTYPE=image/jpeg:https://nbio.uw.edu/wp-content/uploads/2025/09/placeholder-image20191017_UW-Bothell-Campus-10_17_0317-scaled-e1760646849191.jpg ORGANIZER;CN="UW NBIO":MAILTO:nbio@uw.edu END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20251023T093000 DTEND;TZID=America/Los_Angeles:20251023T103000 DTSTAMP:20260504T132829 CREATED:20250905T210051Z LAST-MODIFIED:20260401T172055Z UID:10000084-1761211800-1761215400@nbio.uw.edu SUMMARY:NBIO Presents: Greg Field\, PhD (UCLA) DESCRIPTION:This seminar is co-sponsored by the Vision Training Grant.\n“Efficient coding and early visual processing: new insights into signal processing and cell type diversity”\nEfficient coding predicts much about early sensory processing\, particularly in the visual system. However\, the impressive diversity of cell types and visual receptive field properties present in the retina have\, thus far\, not been predicted or explained by the theory. Perhaps this is one reason many visual neuroscientist continue to think about visual processing more in terms of labeled lines and cell types serving the needs of specific behavioral niches — e.g.\, ‘looming’ cells for detecting looming predators. I will discuss work from my lab as well as my collaborator\, John Pearson\, that shows the impressive predictive power of efficient coding theory and paints a possible way forward for understanding the origin and diversity of cell types in the early visual system. \n Health Sciences G328 and Zoom URL:https://nbio.uw.edu/event/nbio-presents-greg-field-phd-duke-university-efficient-coding-and-early-visual-processing-new-insights-into-signal-processing-and-cell-type-diversity/ LOCATION:Health Sciences G-328 CATEGORIES:Seminar ATTACH;FMTTYPE=image/jpeg:https://nbio.uw.edu/wp-content/uploads/2025/09/Field_Greg-scaled-e1758566415134.jpg ORGANIZER;CN="UW NBIO":MAILTO:nbio@uw.edu END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20251022T190000 DTEND;TZID=America/Los_Angeles:20251022T210000 DTSTAMP:20260504T132829 CREATED:20251016T200744Z LAST-MODIFIED:20251016T200956Z UID:10000117-1761159600-1761166800@nbio.uw.edu SUMMARY:Neuroscience\, AI\, and Society: Justin Smith-Ruiu "How to Survive Death: Moral personhood and the limits of the continuity-of-consciousness argument" DESCRIPTION:How to Survive Death: Moral personhood and the limits of the continuity-of-consciousness argument\nPhilosophers habitually speak of consciousness-uploading and self-uploading as if these were the same thing. In so doing they take for granted the correctness of a broadly Lockean account of personal identity\, according to which I remain the same person from moment to moment\, or perhaps someday from eon to eon\, in virtue of the continuity of conscious memory. Woody Allen\, too\, was following in Locke’s footsteps when he joked: “I do not want to live on in the hearts of my countrymen\, I want to live on in my apartment.” But is ongoing temporal duration from a distinct node of subjective experience really the only way to keep on being a person? Cross-cultural considerations show that many human groups make use of extremely low-tech devices for personhood-uploading —effigies\, story-boards\, tree-trunks—\, and they hardly expect these objects\, after the transfer of the deceased kin’s identity into them\, to pass the Turing test or to display any observable signs of consciousness at all. “Yes\, but they’re just imagining things\,” you’ll say. Fair enough\, but perhaps we are as well. If we are ever going to succeed at exploiting substrate-neutrality to evade or postpone mortality\, it will be necessary not only to follow the right roadmap towards whole-brain emulation in effecting a high-fidelity transfer of consciousness from one substrate to another. It will also be necessary to examine our longstanding presumption\, these days proliferated almost entirely without argument\, that personhood and consciousness are identical. In this talk I will make a first stab at just such an examination\, drawing in particular on the work of Bostrom\, Chalmers\, Parfit\, and Charles Taylor\, as well as on what I take to be salient examples of radically different conceptions of personhood from the ethnographic and historical record of human representations of reality and of our place in it. URL:https://nbio.uw.edu/event/cnc-presents-justin-smith-ruiu-university-of-paris/ LOCATION:Foege Genome Sciences Auditorium S-060\, 3720 15th Ave NE\, Seattle\, WA\, 98195\, United States CATEGORIES:Seminar ATTACH;FMTTYPE=image/png:https://nbio.uw.edu/wp-content/uploads/2025/10/Screenshot-2025-10-16-at-1.05.26-PM.png ORGANIZER;CN="UW Computational Neuroscience Center (CNC)":MAILTO:compneuro@u.washington.edu END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20251017T110000 DTEND;TZID=America/Los_Angeles:20251017T120000 DTSTAMP:20260504T132829 CREATED:20251016T193602Z LAST-MODIFIED:20251016T194554Z UID:10000116-1760698800-1760702400@nbio.uw.edu SUMMARY:NAPE Center Presents: Jose Moron- Concepcion\, PhD (Washington Univ. in St. Louis) DESCRIPTION:“The role of sex and ovarian hormones in pain-induced facilitation of opioid intake”\nOpioid analgesics can alleviate pain symptoms but also have considerable addiction potential. Endogenous opioids and opioid analgesics alike also modulate reward\, stress and negative affect –processes typically dysregulated in drug addiction. Dr. Moron-Concepcion will present findings on how inflammatory pain increases fentanyl self-administration in rodents\, with a focus on sex differences and ovarian hormones. \nHealth Sciences K-069 URL:https://nbio.uw.edu/event/nape-center-presents-jose-moron-concepcion-phd-washington-univ-in-st-louis/ LOCATION:Health Sciences K-069 CATEGORIES:Seminar ATTACH;FMTTYPE=image/jpeg:https://nbio.uw.edu/wp-content/uploads/2025/10/josehead-e1760643355262.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20251016T093000 DTEND;TZID=America/Los_Angeles:20251016T103000 DTSTAMP:20260504T132829 CREATED:20250905T204653Z LAST-MODIFIED:20260401T171618Z UID:10000083-1760607000-1760610600@nbio.uw.edu SUMMARY:NBIO Presents: Martha Bagnall\, PhD (Washington University in St. Louis School of Medicine) DESCRIPTION:“Sensorimotor circuits in the larval zebrafish”\n Health Sciences G328 and Zoom \n  URL:https://nbio.uw.edu/event/nbio-presents-martha-bagnall-phd-washington-university-school-of-medicine-sensorimotor-circuits-in-the-larval-zebrafish/ LOCATION:Magnuson Health Sciences Center\, University of Washington\, NE Pacific Street\, Seattle\, WA\, 98195\, United States CATEGORIES:Seminar ATTACH;FMTTYPE=image/jpeg:https://nbio.uw.edu/wp-content/uploads/2025/09/Martha-Bagnall-1-copy-scaled-e1758566122449.jpg ORGANIZER;CN="UW NBIO":MAILTO:nbio@uw.edu END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20251003T150000 DTEND;TZID=America/Los_Angeles:20251003T160000 DTSTAMP:20260504T132829 CREATED:20250929T180004Z LAST-MODIFIED:20250929T180004Z UID:10000115-1759503600-1759507200@nbio.uw.edu SUMMARY:CNC Presents: Farzaneh Najafi\, PhD (Georgia Institute of Technology) DESCRIPTION:“Temporal signaling\, not predictive processing\, shapes cell type specific dynamics in visual and parietal cortex”\nNeural activity following regular sensory events can reflect either elapsed time since the previous event (temporal signaling) or temporal predictions and prediction errors about the next event (temporal predictive processing). These mechanisms are often confounded\, yet dissociating them is essential for understanding neural circuit computations. We addressed this by performing two-photon calcium imaging from distinct cell types (excitatory\, VIP and SST) in layer 2/3 of visual (VIS) and posterior parietal cortex (PPC)\, while awake mice passively viewed audio-visual stimuli under temporal contexts with different inter-stimulus interval (ISI) distributions. Computational modeling revealed distinct functional clusters of neurons\, including stimulus-activated (ramp-down) and stimulus-inhibited (ramp-up) categories\, with distinct kinetics and area/cell-type biases. Importantly\, all functional clusters were invariant to temporal predictability\, shifted immediately when temporal statistics changed\, and were identical between naive and experienced mice. Population decoding revealed that clusters with heterogeneous kinetics differed in how well they represented interval information\, such that together they tiled elapsed time and produced a distributed\, learning-independent population code for time. These results provide strong evidence against temporal predictive processing in Vis/PPC under passive conditions and instead demonstrate intrinsic coding of interval timing\, redefining the mechanistic origin of ramping and omission-related activity in sensory cortex. We discuss how these dynamics align with stimulus-reset attractor frameworks\, and propose that temporal predictive processing is more likely implemented in other circuits or recruited in Vis/PPC during task-engaged behavior. \n Health Sciences G328 URL:https://nbio.uw.edu/event/cnc-presents-farzaneh-najafi-phd-georgia-institute-of-technology/ LOCATION:Magnuson Health Sciences Center\, University of Washington\, NE Pacific Street\, Seattle\, WA\, 98195\, United States CATEGORIES:Seminar ATTACH;FMTTYPE=image/png:https://nbio.uw.edu/wp-content/uploads/2025/09/Screenshot-2025-09-29-at-10.57.39-AM-e1759168777621.png ORGANIZER;CN="UW Computational Neuroscience Center (CNC)":MAILTO:compneuro@u.washington.edu END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20250930T093000 DTEND;TZID=America/Los_Angeles:20250930T103000 DTSTAMP:20260504T132829 CREATED:20250902T203420Z LAST-MODIFIED:20260401T171513Z UID:10000081-1759224600-1759228200@nbio.uw.edu SUMMARY:NBIO Presents: Pavan Ramdya\, PhD (Ecole Polytechnique Federale de Lausanne) DESCRIPTION:“How flies learn to engage with objects and each other”\nA central goal shared by neuroscience and robotics is to understand how systems can navigate and act autonomously in complex environments. While extensive research has revealed how the visual system segments natural scenes into distinct components—insights that have inspired advances in computer vision and robotics—the next crucial challenge remains: learning the properties of these objects and responding appropriately. In this talk\, I will present our work using the fruit fly Drosophila melanogaster to investigate how the brain learns about objects and other animals in its environment\, and how it uses that information to guide behavior. By integrating quantitative behavioral analysis\, genetic manipulation\, connectomics\, and neural recordings\, we aim to uncover the neural mechanisms that enable flexible\, adaptive interactions with the world. \n Health Sciences G328 and Zoom URL:https://nbio.uw.edu/event/nbio-presents-pavan-ramdya-ecole-polytechnique-federale-de-lausanne-2/ LOCATION:Magnuson Health Sciences Center\, University of Washington\, NE Pacific Street\, Seattle\, WA\, 98195\, United States CATEGORIES:Seminar ATTACH;FMTTYPE=image/jpeg:https://nbio.uw.edu/wp-content/uploads/2025/09/pavan-e1756848684335.jpg ORGANIZER;CN="UW NBIO":MAILTO:nbio@uw.edu END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20250926T140000 DTEND;TZID=America/Los_Angeles:20250926T150000 DTSTAMP:20260504T132829 CREATED:20250923T173102Z LAST-MODIFIED:20250923T173419Z UID:10000112-1758895200-1758898800@nbio.uw.edu SUMMARY:UW Biology Presents a Special Seminar: Communicating Science in Urgent Times featuring Dr. Diego Golombek\, PhD (Universidad de San Andres) DESCRIPTION:Communicating Science in Urgent Times\nDr. Golombek is a neuroscientist and arguably the most important science outreach voice in the Spanish-speaking world.\nPhD in Biology (Universidad de Buenos Aires). Plenary Professor (Universidad de San Andrés)\, Superior Investigator at the National Research Council. Director\, Laboratory for the Interdisciplinary Study of Time. He has published over 190 scientific papers (h-index 42). Besides chronobiology\, he has been interested in science communication/outreach\, publishing about 20 popular science books\, hosting TV shows and creating science exhibitions. Past president of the Argentinean Society for Neuroscience\, the National Program for Science Popularization\, the National Institute for Technological Education and the National Science Center. He received\, among others\, the National Science Prize “Bernardo Houssay”\, the Guggenheim fellowship\, the Konex Prize\, the IgNobel award\, the “Capital City” (Mexico)\, the UNESCO Kalinga Prize (the most important international award in science communication) and the Order of Academic Palms (France).\n\n\n Life Sciences Building 201 URL:https://nbio.uw.edu/event/uw-biology-presents-dr-diego-golombek/ LOCATION:Life Sciences Building\, 3747 W Stevens Wy NE\, Seattle\, WA\, 98195\, United States CATEGORIES:Seminar ATTACH;FMTTYPE=image/jpeg:https://nbio.uw.edu/wp-content/uploads/2025/09/Golombek.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20250925T093000 DTEND;TZID=America/Los_Angeles:20250925T103000 DTSTAMP:20260504T132829 CREATED:20250909T204038Z LAST-MODIFIED:20260401T171353Z UID:10000109-1758792600-1758796200@nbio.uw.edu SUMMARY:NBIO Presents: Tenzin Ngodup\, PhD (Virginia Merrill Bloedel Hearing Research Center\, UW) DESCRIPTION:“Unraveling the Cellular and Synaptic Architecture of the Cochlear Nucleus“\nUnderstanding how the brain processes sound starts with identifying its basic cellular components. Using modern profiling methods\, we have uncovered a rich and previously unappreciated diversity of neuronal types in the lower auditory system. These findings provide a new framework for understanding the synaptic signaling\, neuromodulation\, and circuit organization in the auditory brainstem. \n Health Sciences G328 and Zoom URL:https://nbio.uw.edu/event/nbio-presents-tenzin-ngodup-phd-uw-otolaryngology-head-neck-surgery/ LOCATION:Magnuson Health Sciences Center\, University of Washington\, NE Pacific Street\, Seattle\, WA\, 98195\, United States CATEGORIES:Seminar ATTACH;FMTTYPE=image/jpeg:https://nbio.uw.edu/wp-content/uploads/2025/09/Photo-scaled-e1757704812734.jpg ORGANIZER;CN="UW NBIO":MAILTO:nbio@uw.edu END:VEVENT END:VCALENDAR