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SUMMARY:NBIO Presents:  Xiaoyin Chen\, PhD (Allen Institute)
DESCRIPTION:Understanding brain variations using scalable barcoded connectomics and spatiomics\nHumans and other animals exhibit a wide range of behaviors that are both species-specific and variable within a species. Both types of behavioral variations are enabled by genetic\, molecular\, and circuit variations in the brain. Mapping and comparing brain-wide variations at cellular resolution across a population\, however\, remains a tremendous challenge. My lab aims to solve this challenge by developing in situ sequencing and barcoded connectomics tools. These tools are scalable to brain-wide interrogation across populations and sufficiently low-cost to be applied by individual labs\, and allow us to understand molecular and circuit variations with unprecedented details. In this talk\, I will discuss three related studies in which we use these approaches to reveal how the visual cortex and thalamus develop and adapt from mouse to marmoset and macaque. Finally\, I will discuss preliminary data that aim to reveal how individual variations impact brain-wide organization at the molecular level. \n Health Sciences G328 and Zoom
URL:https://nbio.uw.edu/event/nbio-presents-xiaoyin-chen-allen-institute-2/
LOCATION:Health Sciences G-328
CATEGORIES:Seminar
ATTACH;FMTTYPE=image/jpeg:https://nbio.uw.edu/wp-content/uploads/2025/09/Xiaoyin_Chen_SQUARE-e1757108830744.jpg
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