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SUMMARY:NBIO Presents: Christopher Lapointe\, PhD (Fred Hutchinson Cancer Center)
DESCRIPTION:“Dynamic branchpoints regulate selection of translation start codons”\nTo establish the reading frame for protein synthesis\, the human translation initiation machinery must recognize the translation start codon (AUG) with single-nucleotide precision. Yet\, foundational studies in the 1980’s demonstrated that non-AUG start codons (e.g.\, CUG) can also drive protein synthesis. More recent studies indicate widespread and regulated use of non-AUG codons\, with critical roles in the cell cycle\, stress responses\, and disease. I will share how we have been applying single-molecule\, biochemical\, and structural strategies to understand how the initiation machinery balances the need for both precision and flexibility. \n Health Sciences G-328 and Zoom.
URL:https://nbio.uw.edu/event/nbio-presents-christopher-lapointe-phd-fred-hutchinson-cancer-center/
LOCATION:Health Sciences G-328
CATEGORIES:Seminar
ATTACH;FMTTYPE=image/jpeg:https://nbio.uw.edu/wp-content/uploads/2025/09/Christopher-Lapointe-Crop-scaled-e1770069687899.jpg
ORGANIZER;CN="UW NBIO":MAILTO:nbio@uw.edu
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