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DTSTART;TZID=America/Los_Angeles:20251003T110000
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CREATED:20250929T175316Z
LAST-MODIFIED:20250929T175316Z
UID:10000114-1759489200-1759492800@nbio.uw.edu
SUMMARY:NAPE Center Seminar Series: Larry Zweifel\, PhD (UW Psychiatry & Behavioral Sciences)
DESCRIPTION:“Molecular approaches for resolving the regulation of the midbrain dopamine system”\nWe have developed multiple molecular approaches to perform comprehensive analysis of the genetic heterogeneity midbrain dopamine neurons\, the circuits that control them\, the signaling pathways that regulate them\, and the ion channels that give them their signature encoding properties. I will summarize our current views on how the system is organized to mediate its many functions. \n  \n Health Sciences K069
URL:https://nbio.uw.edu/event/nape-center-seminar-series-larry-zweifel-phd-uw-psychiatry-behavioral-sciences/
LOCATION:Magnuson Health Sciences Center\, University of Washington\, NE Pacific Street\, Seattle\, WA\, 98195\, United States
ATTACH;FMTTYPE=image/png:https://nbio.uw.edu/wp-content/uploads/2025/09/Zweifel_Larry-e1759168346520.png
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LAST-MODIFIED:20250929T180004Z
UID:10000115-1759503600-1759507200@nbio.uw.edu
SUMMARY:CNC Presents: Farzaneh Najafi\, PhD (Georgia Institute of Technology)
DESCRIPTION:“Temporal signaling\, not predictive processing\, shapes cell type specific dynamics in visual and parietal cortex”\nNeural activity following regular sensory events can reflect either elapsed time since the previous event (temporal signaling) or temporal predictions and prediction errors about the next event (temporal predictive processing). These mechanisms are often confounded\, yet dissociating them is essential for understanding neural circuit computations. We addressed this by performing two-photon calcium imaging from distinct cell types (excitatory\, VIP and SST) in layer 2/3 of visual (VIS) and posterior parietal cortex (PPC)\, while awake mice passively viewed audio-visual stimuli under temporal contexts with different inter-stimulus interval (ISI) distributions. Computational modeling revealed distinct functional clusters of neurons\, including stimulus-activated (ramp-down) and stimulus-inhibited (ramp-up) categories\, with distinct kinetics and area/cell-type biases. Importantly\, all functional clusters were invariant to temporal predictability\, shifted immediately when temporal statistics changed\, and were identical between naive and experienced mice. Population decoding revealed that clusters with heterogeneous kinetics differed in how well they represented interval information\, such that together they tiled elapsed time and produced a distributed\, learning-independent population code for time. These results provide strong evidence against temporal predictive processing in Vis/PPC under passive conditions and instead demonstrate intrinsic coding of interval timing\, redefining the mechanistic origin of ramping and omission-related activity in sensory cortex. We discuss how these dynamics align with stimulus-reset attractor frameworks\, and propose that temporal predictive processing is more likely implemented in other circuits or recruited in Vis/PPC during task-engaged behavior. \n Health Sciences G328
URL:https://nbio.uw.edu/event/cnc-presents-farzaneh-najafi-phd-georgia-institute-of-technology/
LOCATION:Magnuson Health Sciences Center\, University of Washington\, NE Pacific Street\, Seattle\, WA\, 98195\, United States
CATEGORIES:Seminar
ATTACH;FMTTYPE=image/png:https://nbio.uw.edu/wp-content/uploads/2025/09/Screenshot-2025-09-29-at-10.57.39-AM-e1759168777621.png
ORGANIZER;CN="UW Computational Neuroscience Center (CNC)":MAILTO:compneuro@u.washington.edu
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